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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Professionalism and Ethical Practice15%- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
Topic 2: Study Design and Conduct17%- Study planning
  • 1. Protocol development and amendments
  • 2. Study population and eligibility criteria
  • 3. Sample size and statistical considerations
- Study implementation
  • 1. Study monitoring and oversight
  • 2. Investigational product management
  • 3. Site selection and activation
Topic 3: Ethical and Participant Safety Considerations19%- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Clinical care and management of research participants
  • 1. Informed consent development and review
  • 2. Standard of care vs protocol requirements
  • 3. Continuity of medical care
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
Topic 4: Data Management and Informatics17%- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
Topic 5: Clinical Study Operations15%- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
Topic 6: Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- ICH Guidelines
  • 1. E6(R2)/E6(R3) Good Clinical Practice
  • 2. E2A Expedited Reporting
  • 3. E11 Pediatric Trials
  • 4. E9 Statistical Principles
  • 5. E8 General Considerations for Clinical Trials
- International standards
  • 1. Declaration of Helsinki

ACRP Certified Professional Sample Questions:

Question 1

Per the protocol, participants' blood creatinine level must be no greater than 2.5 times the upper limit of normal (0.7-1.2 mg/dL). What is the maximum creatinine level the participant can have and be eligible for the trial?

A. 2.6 mg/dL
B. 3.6 mg/dL
C. 3.0 mg/dL
D. 1.8 mg/dL


Question 2

Upon receipt of temperature-controlled IP, the study staff noticed the IP incurred a temperature excursion during transport. What should the staff do NEXT?

A. Dispose of IP and request replacement from sponsor.
B. Quarantine IP without registering in IWRS and request replacement from sponsor.
C. Register IP in IWRS, quarantine and notify sponsor of the excursion.
D. Register IP in IWRS and continue with subject allocation.


Question 3

A deferred consent can take place in which of the following situations?

A. In an emergency situation only, when this process is described in the protocol and has received permission from the ethics committee.
B. Only when the PI approves such a consent process, regardless of the emergency situation described in the protocol.
C. In an emergency situation only, even when this process is not described in the protocol, but the sponsor approves the consent process.
D. Only when the PI approves such a consent process immediately prior to patient enrollment, regardless of the situation being classed as emergency.


Question 4

Who is responsible for submitting a protocol amendment to the IRB/IEC?

A. Sponsor
B. Investigator
C. CRC
D. CRA


Question 5

The CRC is prepared to consent a cognitively impaired participant to an Alzheimer's clinical trial. The CRC is required to utilize which of the following in the consent process?

A. A family member
B. A member of the research team
C. A legally acceptable representative
D. A witness


Solutions:

Question 1
Answer: C
Question 2
Answer: C
Question 3
Answer: A
Question 4
Answer: B
Question 5
Answer: C

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